Deprotonation of beta-cyclodextrin in alkaline solutions.

Evaluation of antioxidant and anti-cancer properties of curcumin / beta- and gamma-cyclodextrin complexes modified with chitosan nanoparticles on lung cancer cell A549

The aim of this study was to investigate the interaction modification of curcumin complex molecule (CUR) in beta- and gamma-cyclodextrin (β-CD and γ-CD) carriers with chitosan (CS) nanoparticles for targeted drug delivery and to compare their performance. The targeted drug delivery system includes the therapeutic agent of the CS nanoparticles targeting section of the same drug and the CD carrie...

Effect of hydroxylpropyl-β-cyclodextrin on Solubility of Carvedilol

The present study was undertaken to examine the effect of pH and concentration of hydroxypropyl-beta-cyclodextrin on the solubility of carvedilol as it shows pH-dependent solubility. The equilibrium solubility of carvedilol in a series of solutions of varying pH (from 1.2 to 11) was determined and compared with the equilibrium solubility of carvedilol in the presence of 20% hydroxypropyl-beta-c...

Effects of ionized cyclodextrin on decomposition of allyl isothiocyanate in alkaline solutions.

The secondary hydroxyl ion (alkoxide) ion for cyclodextrin (CD) may affect the decomposition of allyl isothiocyanate (AITC) in alkaline solutions. The equilibrium and kinetic parameters involved in the reaction processes were measured. It was found that the interaction between the alkoxide ion for CD and the included AITC occurred more than pKa 12.7. From the identified kinetic parameters and d...

The Effect of Beta-Cyclodextrin on the Iodometric Determination of Some Penicillins Reported in USP and BP

In vitro evaluation of natural and methylated cyclodextrins as buccal permeation enhancing system for omeprazole delivery.

In this work the enhancing effect of cyclodextrins on the buccal permeation of a hydrophobic model drug, omeprazole was studied. First, the influence of the complexation with cyclodextrins in the absence and in the presence of an alkali agent, L-arginine, on the drug stability was checked at neutral conditions since omeprazole alone is only stable in basic conditions. In vitro transbuccal perme...